最新研究首次证实!新会陈皮提取物可缓解慢阻肺病样病理改变
近日,广州医科大学呼吸疾病全国重点实验室/广州实验室钟南山院士团队联合深圳大学过敏反应与免疫学研究所、陈皮江门丽宫国际食品等单位(下称“课题组”)在Food&Function发表题目为“Citrus peel extract protects against diesel exhaust particle-induced chronic obstructive pulmonary disease-like lung lesions and oxidative stress”研究论文(陈皮提取物保护了PM2.5诱导的缓解慢阻肺病理损伤以及氧化应激)。
据了解,慢性阻塞性肺疾病(COPD)是肺病全球第三大死因,其主要病理特征为肺气肿、理改小气道重塑和粘液分泌过多。最新证实陈皮具有药食同源特点,研究样病已被广泛应用在食品及中药方剂,首次用于预防及治疗慢性疾病。陈皮广陈皮比陈皮更优质,缓解而广陈皮又以新会陈皮质量最优。慢阻
鉴于陈皮富含抗氧化剂和抗炎化合物,肺病课题组假设陈皮摄入可以抑制PM2.5诱导的氧化应激和炎症反应,从而减轻空气污染物诱导的COPD样病理改变。课题组分别通过体内、体外实验探讨以上研究假设。
体内研究显示,陈皮提取物可有效降低大鼠支气管肺泡灌洗液(BALF)中的炎症细胞数量和炎症介质(IL-17A和TNF-α)浓度;陈皮提取物预处理还显著降低了PM2.5诱导的COPD大鼠血清和肺组织中的氧化应激水平;此外,陈皮提取物预处理有效地减少了大鼠气道的杯状细胞增生和纤维化程度,并减少了肺组织巨噬细胞浸润以及外周肺组织的黑炭沉积,缓解了PM2.5诱导的COPD大鼠肺气肿和小气道重塑。
体外自由基清除实验揭示了陈皮提取物具有清除DPPH自由基的强大能力,并显著降低了PM2.5诱导支气管上皮细胞(BEAS-2B)的ROS产生水平以及增强SOD活性、减弱了BEAS-2B细胞炎症因子(IL-8)和黏蛋白(MUC5AC)的高表达。机制实验显示,陈皮提取物能够通过上调Nrf-2蛋白质水平、并抑制MAPK/NF-κB信号传导途径(抑制p38,JNK和p65磷酸化水平)来发挥抗炎、抗氧化功效。总而言之,课题组首次证实了陈皮提取物可有效降低PM2.5诱导的外周肺损伤以及氧化应激水平,进而缓解了COPD样病理改变。
论文摘要图示。
课题组采用新会陈皮(GC)开展陈皮水提物的主要化学组成分析,定量结果显示橙皮苷的含量最高(102.9 mg/100 g),其次是辛弗林(29.0 mg/100g)、川陈皮素(24.0 mg/100g)、橘皮素(21.9 mg/100g)以及柚皮苷(11.0 mg/100g);此外,多甲氧基黄酮类物质也被检出。
GC水提物中主要化学成分的分布和定量结果。
陈皮水提物具有强大的清除氧自由基能力,降低了PM2.5诱导COPD大鼠的气道炎症,延缓了PM2.5诱导的慢阻肺样病理进展,延缓了PM2.5诱导COPD大鼠气道粘液高分泌及纤维化,降低了PM2.5诱导COPD大鼠氧化应激水平,在呼吸道上皮细胞模型中展现了强大的抗炎、抗氧化功效。(原文链接:https://doi.org/10.1039/D3FO02010J)
【记者】张济翔
【来源】南方农村报
(责任编辑:产品中心)
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